DEPARTMENT OF COMMUNITY HEALTH

            		  BUREAU OF LABORATORIES

                      HUMANE CARE AND USE OF ANIMALS


(By authority conferred on the department of  public  health  by  sections
2226(d), 2233, and 2678 of Act No. 368 of the  Public  Acts  of  1978,  as
amended, and section 9 of Act No. 380 of  the  Public  Acts  of  1965,  as
amended, being  SS333.2226(d),  333.2233,  333.2678,  and  16.109  of  the
Michigan Compiled Laws)


R  325.921   Definitions.
  Rule 1. (1) As used in these rules:
  (a) "Animal" means any living, vertebrate animal.
  (b) "Animal facility" means any physical area or areas where animals are
cared for or used.
  (c) "Authorized representative" means the individual who is  responsible
to the department for the care  and  use  of  animals  within  the  animal
facility and who is  authorized  to  sign  the  application  form  by  the
applicant.
  (d) "Care," with  respect  to  animals,  means  all  of  those  elements
associated  with  laboratory  animal  management,  including  all  of  the
following:
  (i) Housing (buildings, ventilation, cage size,  structural  materials).
  (ii) Sanitation (cleanliness, waste disposal, pest control).
  (iii) Personal hygiene.
  (iv) Safety of the animal care staff.
  (v) Husbandry (cage groupings, feed, water temperature, bedding,  animal
health, reproduction, nutrition).
  (vi) Veterinary medical care.
  (e) "Code" means Act No. 368 of the Public Acts  of  1978,  as  amended,
being S333.1101 et seq. of the Michigan Compiled Laws, and  known  as  the
public health code.
  (f) "Department" means the Michigan department of public health.
  (g) "Guide" means the guide for the care and use of laboratory  animals,
department of  health,  education,  and  welfare,  no. (NIH)  78-23,  1978
edition.
  (h)  "Person"  means  any  individual,  laboratory,  firm,  association,
corporation, partnership, trust, estate, educational institution, or other
legal entity.
  (i) "Use of animals for experimental purposes" means use of animals  for
the diagnosis and treatment of human and animal diseases; the  advancement
of veterinary, dental, medical, and biological sciences; and the  testing,
diagnosis,  improvement,  and  standardization  of  laboratory  specimens,
biologic products, pharmaceuticals, and drugs.
  (2) Unless the context requires otherwise, terms  defined  in  the  code
have the same meaning when used in these rules.

  History:  1980 AACS.


R  325.922   Registration for the care and use of animals for experimental
purposes.
  Rule 2. (1) A person shall make  application  to  the  department  as  a
condition of registration for the care and use of  laboratory  animals.  A
person shall not care for or use animals for experimental purposes  unless
registered to do so by the department.
  (2) Application for registration shall be made on forms provided by  the
department and shall include all of the following:
  (a) The name and address of the person applying.
  (b)  The  name,  signature,  and  address  of  the  person's  authorized
representative.
  (c) Other information deemed  appropriate  by  the  department  for  the
determination of compliance with these rules.
  (3) The department shall grant registration for  the  care  and  use  of
animals for experimental purposes when it determines that  such  care  and
use meet all of the following conditions:
  (a)  The  care  and  use  are  conducted  by,  or  under  the  immediate
supervision of, personnel qualified by professional training.
  (b) The facilities and procedures used for the care and use  of  animals
in the  laboratory  animal  facility  or  facilities  are  in  substantial
conformance with those outlined in the guide and these rules.
  (c) The guide is used as a standard reference for the determination  and
evaluation of the proper care and use of animals in the laboratory  animal
facility or facilities.
  (4) Registration shall  be  granted  in  the  name  of  the  applicant's
authorized representative on forms provided by the department.
  (5) The individual whose name appears as the  authorized  representative
on the registration shall be responsible to the department  for  the  care
and use of animals.  An  authorized  representative  shall,  upon  written
request by the department, furnish a current list containing the names and
qualifications of those individuals directly responsible to him or her for
the care and use of animals.

  History:  1980 AACS.


R  325.923   Care  of  animals;  use  of  anesthetics,   analgesics,   and
tranquilizers; post-experimental care; transporting animals.
  Rule 3. (1)  A  registrant  shall  give  careful  consideration  to  the
physical comfort of animals wherever located. Care shall be given  in  all
cases in a manner which will assure the welfare of  the  animals  and  the
safety of the animal care staff.
  (2)  Anesthetics,  analgesics,  and  tranquilizers  shall  be  used   in
accordance with the guide. The use and choice of the most appropriate drug
or drugs are matters of professional judgment and shall be determined  by,
or in consultation with, a  qualified  scientist  or  veterinarian.  If  a
painful procedure must be conducted without  the  use  of  an  anesthetic,
analgesic, or tranquilizer because such use would defeat the purpose of an
experiment, the procedure shall be supervised by a responsible  scientist.
  (3) Post-experimental care of animals shall be such as to minimize  pain
and discomfort and the  consequences  of  any  disability  resulting  from
experimentation  in  accordance  with  accepted  practices  in  veterinary
medicine. If, at the conclusion of an investigation, an animal cannot live
without permanent pain or prolonged discomfort, it shall be  humanely  and
painlessly destroyed. When an  animal  is  euthanized,  it  shall  not  be
discarded until death is certain.
  (4) A registrant who provides transportation for animals, whether within
the facility  or  between  facilities,  shall  arrange  for  their  humane
handling during such transportation.

  History:  1980 AACS.


R  325.924   Inspection of animal facilities.
  Rule 4. (1) The animal facility or facilities of each  registrant  shall
be inspected annually at any reasonable time as may be designated  by  the
department.
  (2) When the animal facility or  facilities  are  inspected,  the  guide
shall be used as the standard for evaluation.
  (3) Interim inspections may be made  at  such  other  times  as  may  be
determined by the department.
  (4) The department representative conducting an inspection shall display
his or her credentials and his or her authorization from  the  department.
  (5)  Every  individual  who  participates  in   an   inspection   as   a
representative of the department shall promptly report, in writing, his or
her findings to the department and to the registrant.
  (6) A registrant found, upon inspection, to be  in  violation  of  these
rules or to possess major deficiencies with  respect  to  compliance  with
these rules may be placed on probation. If, after a reasonable  amount  of
time, substantial compliance is not  achieved,  the  registration  may  be
limited or revoked in accordance with Act No. 306 of the  Public  Acts  of
1969, as amended, being S24.201 et seq. of the Michigan Compiled Laws.

  History:  1980 AACS.


R  325.925   Adoption by reference
  Rule 5. The provisions set forth in the guide are adopted in these rules
by reference. Copies of the guide are available from the Superintendent of
Documents,  U.S. Government  Printing  Office,  Washington,  D.C.,   (DHEW
publication (NIH) 78-23, rev. 1978)  at  a  cost  of  $2.20  or  from  the
Michigan Department of  Public  Health,  Bureau  of  Disease  Control  and
Laboratory Services,  3500  N. Martin  Luther  King,  Jr. Blvd.,  P.O. Box
30035, Lansing, Michigan 48909 at a cost of $2.20.

  History:  1980 AACS.


R  325.926   Rescission.
  Rule 6. R 325.981 to R 325.992  of  the  Michigan  Administrative  Code,
appearing on pages 1775 and 1776 of the 1979 Michigan Administrative Code,
are rescinded.

  History:  1980 AACS.